Jan 09, 2020· Increasing compression force and dwell time are often helpful in reducing sticking and picking. Generally, increases in compression force can assist with forming a more robust tablet. Extended head flats can be used to increase dwell time (the time the head flat spends under the pressure roll) while maintaining a given press speed (RPM), as longer dwell times generally result in a more robust tablet.
compression pressure to reduce sticking may lead to heating issues in the tablet press, as these factors require the device gearbox to be operated at levels that may generate signi fi cant heat
Feb 03, 2020· In this case, there are two possibilities to remedy the problem. The first remedy is to reduce the amount of binder used in the manufacturing process. Alternatively, the binder in question can also be changed so as to prevent the tablet sticking problem. Moreover, tablet sticking is also brought up by hygroscopic granular materials.
reducing sticking on tableting punches A major cause of sticking on production tableting punches is mechanical interlocking of powders on punch cup surfaces. As the cup faces of tableting punches wear and corrode, the roughened surfaces act to trap powders during compression.
In most cases, picking occurs on the upper side of the tablet as opposed to the lower side. Tablet formation should meet various conditions; lubrication, heating, and cooling. These activities should take place at specific intervals and temperatures. If you fail to incline with the conditions, chances for picking
The slightest imperfections in tableting punch cup surfaces can lead to production problems including sticking and picking. What Causes Sticking and Picking? Mechanical interlocking of formulation powders and slight surface imperfections in punch cup surfaces is responsible for the majority of sticking and picking that occurs in pharmaceutical
Nickel fluoropolymer, a coating in which nickel with a fluoropolymer is deposited by electroless electroplating on the punch, best enhances product release and reduces sticking and picking. However, nickel fluoropolymer is not ideal for all formulations; it can
Adhesion, sticking, picking, and filming on punches and dies can in many cases be avoided by a suitable surface finish of the tooling. In some cases, the surface is smoothened during continuous use of punches, whereas in other cases, depending on the material compressed, e.g., in the case of crystalline lactose, small scratches may occur on the
Reduce granular size, add more fines, and increase the quantity of lubricant. 4. Too hard granules for the lubricant to be effective. Modify granulation. Reduce granular size. 5. Granular material very abrasive and cutting into dies. If coarse granules, reduce its size. Use wear-resistant dies. 6. Granular material too warm, sticks to the die.
Once addressed and identified, these patterns may pave the way for drug formulation to be adjusted to reduce the sticking problem. Current research conducted by Pfizer, for example, is focused on why some APIs stick more than others; the company is also investigating the effects of solid API attributes in relation to sticking.
May 23, 2017· Summary. Poor lubrication results in picking and sticking problems during production. These are one of the most common causes of tablet defects which result in slow running of the tablet press and reduced output.
Sticking and Picking. The sticking defect occurs when the granules of a formulation become stuck to the face of the press punch. Picking, on the other hand, happens when the granules stick to the design embedded in the punch tip such as in lettering or logos. Both sticking and picking result in
Feb 24, 2014· Interestingly, the tableting experiments described above were conducted using turret/punch tip temperatures ranging from 25 C to 34 C. This suggested that reducing the temperature at which compression is performed may help to reduce or eliminate film formation and sticking during tableting of hydrophobic drug mixtures.
The blend was sticking beneath the feeding and getting charred. It is seen in Figure 1B. The blend also was sticking to upper and lower tooling. The tablet surface showed discoloration and picking in the center of the tablet, shown in Figure 1C. Scientists observed that some of the tablets were capped as they came off the press, but no capping
Formulation sticking in the letters and characters of punch embossing is typically referred to as picking. Both result in tablet defects and lower production due to time spent troubleshooting. Solutions to sticking and picking include changing the formulation, increasing compression force,
Adhesion, sticking, picking, and filming on punches and dies can in many cases be avoided by a suitable surface finish of the tooling. In some cases, the surface is smoothened during continuous use of punches, whereas in other cases, depending on the material compressed, e.g., in the case of crystalline lactose, small scratches may occur on the
For example, 'sticking' is a major tablet-production issue that we are trying to tackle through our work with the University of Nottingham on the tableting science anti-stick research (TSAR) project. We hope to deliver a predictive tool that will remove the need to undertake expensive coating trials to determine the best coating solution.
Punch sticking is a known problems in pharmaceutical industry and elsewhere. If not properly formulated, most drugs will stick to punches. Thus, one goal of tablet formulation is to avoid punch
Oct 22, 2013· Picking : (localized adhesion) Filming: is a slow form of sticking and is largely due to excess moisture in the granulation 10/21/2013 20 21. Problems during granulation & compression 2. Picking: is removal of a tablet’s surface material by a punch. In
Apr 17, 2014· Reduce concavity to optimum. 2. Too little pressure. Increase pressure. 3. Compressing too fast. Reduce speed. 28. Picking Small amount of material from a tablet is sticking to and being removed off from the tablet-surface by a punch face. The problem is more prevalent on the upper punch faces than on the lower ones. Fig: Picking[1] 29.
Oct 05, 2020· Sticking: Sticking is the adherence of materials to the die wall. Picking: Picking is removed from materials from the surface of the tablet and its adherence to the face of the punch. Binding: problem likes sticking, picking, and binding due to more amount of Binder in the granules or wet granules. Different compression problems due to other
Tableting Problems: Compression related tablet problems mainly include capping/lamination and sticking/picking. Capping is a term used to describe the partial or complete removal of the top or bottom crown of a tablet from the main body whereas Lamination is the separation of a
Ejection force is the force required the push the tablet out of the die. Ejection stress is calculated from ejection force to account for the punch and die geometries (Stress = Force/Area). It is a measure of how well lubricated the formulation is. Poor lubrication results in tablet defects such as picking, sticking